Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques
Charlotte Rimbault, Christelle Breillat, Benjamin Compans, Estelle Toulmé, Filipe Nunes Vicente, Monica Fernandez-Monreal, Patrice Mascalchi, Camille Genuer, Virginia Puente-Muñoz, Isabel Gauthereau, Eric Hosy, Stéphane Claverol, Gregory Giannone, Ingrid Chamma, Cameron D Mackereth, Christel Poujol, Daniel Choquet, Matthieu Sainlos
eLife. 2024-01-03
10.7554/eLife.69620

MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Andrea Toledo, Mathieu Letellier, Giorgia Bimbi, Béatrice Tessier, Sophie Daburon, Alexandre Favereaux, Ingrid Chamma, Kristel Vennekens, Jeroen Vanderlinden, Matthieu Sainlos, Joris de Wit, Daniel Choquet, Olivier Thoumine
eLife. 2022-05-09
10.7554/elife.75233

High-Resolution Fluorescence Imaging Combined With Computer Simulations to Quantitate Surface Dynamics and Nanoscale Organization of Neuroligin-1 at Synapses.
Matthieu Lagardère, Adèle Drouet, Matthieu Sainlos, Olivier Thoumine
Front. Synaptic Neurosci.. 2022-04-25
10.3389/fnsyn.2022.835427

Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration
Amine Mehidi, Frieda Kage, Zeynep Karatas, Maureen Cercy, Matthias Schaks, Anna Polesskaya, Matthieu Sainlos, Alexis M. Gautreau, Olivier Rossier, Klemens Rottner, Grégory Giannone
Nat Cell Biol. 2021-11-01
10.1038/s41556-021-00786-8

Role of regulatory C‐terminal motifs in synaptic confinement of LRRTM2
Konstantina Liouta, Julia Chabbert, Sebastien Benquet, Béatrice Tessier, Vincent Studer, Matthieu Sainlos, Joris De Wit, Olivier Thoumine, Ingrid Chamma
Biol. Cell. 2021-09-27
10.1111/boc.202100026

High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
Angela M. Getz, Mathieu Ducros, Christelle Breillat, Aurélie Lampin-Saint-Amaux, Sophie Daburon, Urielle François, Agata Nowacka, Mónica Fernández-Monreal, Eric Hosy, Frédéric Lanore, Hanna Zieger, Matthieu Sainlos, Yann Humeau, Daniel Choquet
. 2021-09-22
10.1101/2021.09.21.461215

Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes
Charlotte Rimbault, Christelle Breillat, Benjamin Compans, Estelle Toulmé, Filipe Nunes Vicente, Monica Fernandez-Monreal, Patrice Mascalchi, Camille Genuer, Virginia Puente-Muñoz, Isabel Gauthereau, Eric Hosy, Gregory Giannone, Ingrid Chamma, Cameron D. Mackereth, Christel Poujol, Daniel Choquet, Matthieu Sainlos
. 2021-04-08
10.1101/2021.04.07.438431

Advanced imaging and labelling methods to decipher brain cell organization and function
Daniel Choquet, Matthieu Sainlos, Jean-Baptiste Sibarita
Nat Rev Neurosci. 2021-03-12
10.1038/s41583-021-00441-z

Correction: Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
Kalina T Haas, Benjamin Compans, Mathieu Letellier, Thomas M Bartol Jr, Dolors Grillo-Bosch, Terrence J Sejnowski, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine
eLife. 2020-12-16
10.7554/eLife.65689

Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
Charlotte Rimbault, Kashyap Maruthi, Christelle Breillat, Camille Genuer, Sara Crespillo, Virginia Puente-Muñoz, Ingrid Chamma, Isabel Gauthereau, Ségolène Antoine, Coraline Thibaut, Fabienne Wong Jun Tai, Benjamin Dartigues, Dolors Grillo-Bosch, Stéphane Claverol, Christel Poujol, Daniel Choquet, Cameron D. Mackereth, Matthieu Sainlos
Nat Commun. 2019-10-04
10.1038/s41467-019-12528-4

Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
Morgane Rosendale, Thi Nhu Ngoc Van, Dolors Grillo-Bosch, Silvia Sposini, Léa Claverie, Isabel Gauthereau, Stéphane Claverol, Daniel Choquet, Matthieu Sainlos, David Perrais
Nat Commun. 2019-10-01
10.1038/s41467-019-12434-9

TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering
Edoardo Moretto, Anna Longatti, Luca Murru, Ingrid Chamma, Alessandro Sessa, Jonathan Zapata, Eric Hosy, Matthieu Sainlos, Julien Saint-Pol, Eric Rubinstein, Daniel Choquet, Vania Broccoli, Giampietro Schiavo, Olivier Thoumine, Maria Passafaro
Cell Reports. 2019-10-01
10.1016/j.celrep.2019.09.051

Biophysical mechanisms underlying the membrane trafficking of synaptic adhesion molecules.
Ingrid Chamma, Matthieu Sainlos, Olivier Thoumine
Neuropharmacology. 2019-03-01
10.1016/j.neuropharm.2019.02.037

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models
Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J. David, Frederic Saudou, Yann Humeau, Daniel Choquet
Nat Commun. 2018-10-15
10.1038/s41467-018-06675-3

Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses
Blanka Kellermayer, Joana S. Ferreira, Julien Dupuis, Florian Levet, Dolors Grillo-Bosch, Lucie Bard, Jeanne Linarès-Loyez, Delphine Bouchet, Daniel Choquet, Dmitri A. Rusakov, Pierre Bon, Jean-Baptiste Sibarita, Laurent Cognet, Matthieu Sainlos, Ana Luisa Carvalho, Laurent Groc
Neuron. 2018-10-01
10.1016/j.neuron.2018.09.012

A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation
Mathieu Letellier, Zsófia Szíber, Ingrid Chamma, Camille Saphy, Ioanna Papasideri, Béatrice Tessier, Matthieu Sainlos, Katalin Czöndör, Olivier Thoumine
Nat Commun. 2018-09-28
10.1038/s41467-018-06220-2

Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
Kalina T Haas, Benjamin Compans, Mathieu Letellier, Thomas M Bartol, Dolors Grillo-Bosch, Terrence J Sejnowski, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine, Eric Hosy
eLife. 2018-07-25
10.7554/eLife.31755

CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J. Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K. Ulrich Bayer, Christophe Mulle, Daniel Choquet
Cell Reports. 2018-06-01
10.1016/j.celrep.2018.05.036

Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin
Ingrid Chamma, Olivier Rossier, Grégory Giannone, Olivier Thoumine, Matthieu Sainlos
Nat Protoc. 2017-03-09
10.1038/nprot.2017.010

Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy
Ingrid Chamma, Florian Levet, Jean-Baptiste Sibarita, Matthieu Sainlos, Olivier Thoumine
Neurophoton. 2016-11-03
10.1117/1.NPh.3.4.041810

Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin.
Ingrid Chamma, Mathieu Letellier, Corey Butler, Béatrice Tessier, Kok-Hong Lim, Isabel Gauthereau, Daniel Choquet, Jean-Baptiste Sibarita, Sheldon Park, Matthieu Sainlos, Olivier Thoumine
Nat Comms. 2016-03-16
10.1038/ncomms10773

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.
Anne-Sophie Hafner, Andrew C. Penn, Dolors Grillo-Bosch, Natacha Retailleau, Christel Poujol, Amandine Philippat, Françoise Coussen, Matthieu Sainlos, Patricio Opazo, Daniel Choquet
Neuron. 2015-04-01
10.1016/j.neuron.2015.03.013

Inhibition of PDZ domain-mediated interactions
Dolors Grillo-Bosch, Daniel Choquet, Matthieu Sainlos
Drug Discovery Today: Technologies. 2013-12-01
10.1016/j.ddtec.2012.10.003

Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1
Grégory Giannone, Magali Mondin, Dolors Grillo-Bosch, Béatrice Tessier, Edouard Saint-Michel, Katalin Czöndör, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine
Cell Reports. 2013-06-01
10.1016/j.celrep.2013.05.013

Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions
Matthieu Sainlos, Wendy S. Iskenderian-Epps, Nelson B. Olivier, Daniel Choquet, Barbara Imperiali
J. Am. Chem. Soc.. 2013-03-13
10.1021/ja309870q

Regulation of AMPA receptor surface diffusion by PSD-95 slots
Patricio Opazo, Matthieu Sainlos, Daniel Choquet
Current Opinion in Neurobiology. 2012-06-01
10.1016/j.conb.2011.10.010

Paromomycin and neomycin B derived cationic lipids: Synthesis and transfection studies
Mathieu Mével, Matthieu Sainlos, Benoît Chatin, Noufissa Oudrhiri, Michèle Hauchecorne, Olivier Lambert, Jean-Pierre Vigneron, Pierre Lehn, Bruno Pitard, Jean-Marie Lehn
Journal of Controlled Release. 2012-03-01
10.1016/j.jconrel.2011.12.019

Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.
Matthieu Sainlos, Cezar Tigaret, Christel Poujol, Nelson B Olivier, Lucie Bard, Christelle Breillat, Kevin Thiolon, Daniel Choquet, Barbara Imperiali
Nat Chem Biol. 2010-12-26
10.1038/nchembio.498

Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins
L. Bard, M. Sainlos, D. Bouchet, S. Cousins, L. Mikasova, C. Breillat, F. A. Stephenson, B. Imperiali, D. Choquet, L. Groc
Proceedings of the National Academy of Sciences. 2010-10-25
10.1073/pnas.1002690107

Monitoring protein interactions and dynamics with solvatochromic fluorophores
Galen S. Loving, Matthieu Sainlos, Barbara Imperiali
Trends in Biotechnology. 2010-02-01
10.1016/j.tibtech.2009.11.002

A general screening strategy for peptide-based fluorogenic ligands: Probes for dynamic studies of PDZ domain-mediated interactions
Matthieu Sainlos, Wendy S. Iskenderian, Barbara Imperiali
J. Am. Chem. Soc.. 2009-05-20
10.1021/ja900371q

Synthesis of anhydride precursors of the environment-sensitive fluorophores 4-dmap and 6-dmn
Matthieu Sainlos, Barbara Imperiali
Nat Protoc. 2007-12-01
10.1038/nprot.2007.444

Tools for investigating peptide-protein interactions: Peptide incorporation of environment-sensitive fluorophores through spps-based 'building block' approach
Matthieu Sainlos, Barbara Imperiali
Nat Protoc. 2007-12-01
10.1038/nprot.2007.443

Tools for investigating peptide-protein interactions: Peptide incorporation of environment-sensitive fluorophores via on-resin derivatization
Matthieu Sainlos, Barbara Imperiali
Nat Protoc. 2007-12-01
10.1038/nprot.2007.442

Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference
L. Desigaux, M. Sainlos, O. Lambert, R. Chevre, E. Letrou-Bonneval, J.-P. Vigneron, P. Lehn, J.-M. Lehn, B. Pitard
Proceedings of the National Academy of Sciences. 2007-10-08
10.1073/pnas.0707431104

Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells
Prasanna Venkatraman, Tina T Nguyen, Matthieu Sainlos, Osman Bilsel, Sriram Chitta, Barbara Imperiali, Lawrence J Stern
Nat Chem Biol. 2007-03-11
10.1038/nchembio868

Aminoglycoside-quinacridine conjugates: Towards recognition of the P6.1 element of telomerase RNA
Markus Kaiser, Matthieu Sainlos, Jean-Marie Lehn, Sophie Bombard, Marie-Paule Teulade-Fichou
ChemBioChem. 2006-01-12
10.1002/cbic.200500354

Neomycin-capped aromatic platforms: Quadruplex DNA recognition and telomerase inhibition
Markus Kaiser, Anne De Cian, Matthieu Sainlos, Christian Renner, Jean-Louis Mergny, Marie-Paule Teulade-Fichou
Org. Biomol. Chem.. 2006-01-01
10.1039/b516378a

Kanamycin A-derived cationic lipids as vectors for gene transfection
Matthieu Sainlos, Michelle Hauchecorne, Noufissa Oudrhiri, Samia Zertal-Zidani, Abderrahim Aissaoui, Jean-Pierre Vigneron, Jean-Marie Lehn, Pierre Lehn
ChemBioChem. 2005-05-10
10.1002/cbic.200400344

The design of cationic lipids for gene delivery
B. Martin, M. Sainlos, A. Aissaoui, N. Oudrhiri, M. Hauchecorne, J.- Vigneron, J.- Lehn, P. Lehn
CPD. 2005-02-01
10.2174/1381612053382133

Aminoglycoside-derived cationic lipids for gene transfection: Synthesis of kanamycin A derivatives
Matthieu Sainlos, Philippe Belmont, Jean-Pierre Vigneron, Pierre Lehn, Jean-Marie Lehn
Eur. J. Org. Chem.. 2003-08-01
10.1002/ejoc.200300164

Progress in gene delivery by cationic lipids: Guanidinium-cholesterol based systems as an example
Abderrahim Aissaoui, Noufissa Oudrhiri, Laure Petit, Michelle Hauchecorne, Erwan Kan, Matthieu Sainlos, Sebastien Julia, Jean Navarro, Jean-Pierre Vigneron, Jean-Marie Lehn
CDT. 2002-02-01
10.2174/1389450023348082