A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsy.
Stéphane J. Baudouin, April R. Giles, Nick Pearson, Severine Deforges, Chenxia He, Céline Boileau, Nicolas Partouche, Andreas Borta, Justine Gautron, Morgane Wartel, Irena Bočkaj, Didier Scavarda, Fabrice Bartolomei, Guillaume Penchet, Jérôme Aupy, Jennifer Sims, Jared Smith, Andrew Mercer, Olivier Danos, Christophe Mulle, Valérie Crépel, Richard Porter
Molecular Therapy - Methods & Clinical Development. 2024-12-01
10.1016/j.omtm.2024.101342

GluK2 Is a Target for Gene Therapy in Drug‐Resistant Temporal Lobe Epilepsy
Céline Boileau, Severine Deforges, Angélique Peret, Didier Scavarda, Fabrice Bartolomei, April Giles, Nicolas Partouche, Justine Gautron, Julio Viotti, Haley Janowitz, Guillaume Penchet, Cécile Marchal, Stanislas Lagarde, Agnès Trebuchon, Nathalie Villeneuve, Julie Rumi, Thomas Marissal, Roustem Khazipov, Ilgam Khalilov, Fanny Martineau, Marine Maréchal, Anne Lepine, Mathieu Milh, Dominique Figarella‐Branger, Etienne Dougy, Soutsakhone Tong, Romain Appay, Stéphane Baudouin, Andrew Mercer, Jared B. Smith, Olivier Danos, Richard Porter, Christophe Mulle, Valérie Crépel
Annals of Neurology. 2023-07-06
10.1002/ana.26723

Presenilin and APP regulate synaptic kainate receptors.
Gael Barthet, Ana Moreira- de-Sá, Pei Zhang, Séverine Deforges, Jorge Castanheira, Adam Gorlewicz, Christophe Mulle
J. Neurosci.. 2022-10-26
10.1523/jneurosci.0297-22.2022

(S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist.
Christian B. M. Poulie, Younes Larsen, Cindie Leteneur, Gaël Barthet, Walden E. Bjørn-Yoshimoto, Fanny Malhaire, Birgitte Nielsen, Jean-Phillippe Pin, Christophe Mulle, Darryl S. Pickering, Lennart Bunch
ACS Chem. Neurosci.. 2022-04-27
10.1021/acschemneuro.2c00162

APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?
Tomàs Jordà‐Siquier, Melina Petrel, Vladimir Kouskoff, Una Smailovic, Fabrice Cordelières, Susanne Frykman, Ulrike Müller, Christophe Mulle, Gaël Barthet
Alzheimer's & Dementia. 2022-01-25
10.1002/alz.12546

The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability.
Adam Gorlewicz, Gael Barthet, Stefano Zucca, Peggy Vincent, Marilena Griguoli, Noëlle Grosjean, Grzegorz Wilczynski, Christophe Mulle
Cerebral Cortex. 2021-11-03
10.1093/cercor/bhab390

Regulation and dysregulation of neuronal circuits by KARs.
Christophe Mulle, Valérie Crépel
Neuropharmacology. 2021-10-01
10.1016/j.neuropharm.2021.108699

Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease
Hazal Haytural, Tomàs Jordà-Siquier, Bengt Winblad, Christophe Mulle, Lars O Tjernberg, Ann-Charlotte Granholm, Susanne Frykman, Gaël Barthet
Brain Communications. 2021-04-01
10.1093/braincomms/fcab079

Impaired plasticity of intrinsic excitability in the dentate gyrus alters spike transfer in a mouse model of Alzheimer's disease
Nan Jiang, Dario Cupolillo, Noelle Grosjean, Emeline Muller, Séverine Deforges, Christophe Mulle, Thierry Amédée
Neurobiology of Disease. 2021-03
10.1016/j.nbd.2021.105345

Lighting up pre‐synaptic potentiation
Ashley L. Kees, Catherine Marneffe, Christophe Mulle
J Neurochem. 2020-12-04
10.1111/jnc.15236

APP accumulates around dense-core amyloid plaques with presynaptic proteins in Alzheimer’s disease brain
Tomàs Jordà-Siquier, Melina Petrel, Vladimir Kouskoff, Fabrice Cordelières, Susanne Frykman, Ulrike Müller, Christophe Mulle, Gaël Barthet
Preprint bioRxiv. 2020-10-16
10.1101/2020.10.16.342196

Theta Oscillations Coincide with Sustained Hyperpolarization in CA3 Pyramidal Cells, Underlying Decreased Firing
Meryl Malezieux, Ashley L. Kees, Christophe Mulle
Cell Reports. 2020-07-01
10.1016/j.celrep.2020.107868

Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
Benjamin J.A. Robert, Maïté M. Moreau, Steve Dos Santos Carvalho, Gael Barthet, Claudia Racca, Mehdi Bhouri, Anne Quiedeville, Maurice Garret, Bénédicte Atchama, Alice Shaam Al Abed, Christelle Guette, Deborah J. Henderson, Aline Desmedt, Christophe Mulle, Aline Marighetto, Mireille Montcouquiol, Nathalie Sans
Cell Reports. 2020-06-01
10.1016/j.celrep.2020.107743

Colocalization Colormap -an ImageJ Plugin for the Quantification and Visualization of Colocalized Signals.
Adam Gorlewicz, Katarzyna Krawczyk, Andrzej A. Szczepankiewicz, Pawel Trzaskoma, Christophe Mulle, Grzegorz M. Wilczynski
Neuroinform. 2020-05-02
10.1007/s12021-020-09465-9

Presynaptic failure in Alzheimer's disease.
Gael Barthet, Christophe Mulle
Progress in Neurobiology. 2020-05-01
10.1016/j.pneurobio.2020.101801

The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging.
Myriam Abarkan, Julien Gaitan, Fanny Lebreton, Romain Perrier, Manon Jaffredo, Christophe Mulle, Christophe Magnan, Matthieu Raoux, Jochen Lang
Molecular Metabolism. 2019-12-01
10.1016/j.molmet.2019.09.011

Intracellular dynamics of CA3 pyramidal cells supporting sparse coding during theta and large irregular activity
Meryl Malezieux, Ashley L. Kees, Christophe Mulle
Bio Archive. 2019-05-29
10.1101/652461

Hippocampal mossy fibers synapses in CA3 pyramidal cells are altered at an early stage in a mouse model of Alzheimer's disease.
Viana da Silva S., Zhang P., Georg Haberl M., Labrousse V., Grosjean N., Blanchet C., Frick A., Mulle C.
Journal of Neuroscience. 2019-03-18
10.1523/JNEUROSCI.2868-18.2019

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.
Barthet G, Jordà-Siquier T, Rumi-Masante J, Bernadou F, Müller U, Mulle C.
Nat Commun.. 2018 Nov 14
10.1038/s41467-018-06813-x

Activity-dependent control of NMDA receptor subunit composition at hippocampal mossy fibre synapses.
Mario Carta, Bettadapura N. Srikumar, Adam Gorlewicz, Nelson Rebola, Christophe Mulle
J Physiol. 2018-01-30
10.1113/jp275226

Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
Elisabetta Aloisi, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, Matthias Georg Haberl, Lara Costa, Ryuichi Shigemoto, Anke Tappe-Theodor, Filippo Drago, Pier Vincenzo Piazza, Christophe Mulle, Laurent Groc, Lucia Ciranna, Maria Vincenza Catania, Andreas Frick
Nat Commun. 2017-10-24
10.1038/s41467-017-01191-2

Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia
Roberto Carlos Agís‐Balboa, Paulo S Pinheiro, Nelson Rebola, Cemil Kerimoglu, Eva Benito, Michael Gertig, Sanaz Bahari‐Javan, Gaurav Jain, Susanne Burkhardt, Ivana Delalle, Alexander Jatzko, Markus Dettenhofer, Patricia A Zunszain, Andrea Schmitt, Peter Falkai, Julius C Pape, Elisabeth B Binder, Christophe Mulle, Andre Fischer, Farahnaz Sananbenesi
EMBO J.. 2017-08-02
10.15252/embj.201796821

Identification and structure-function study of positive allosteric modulators of kainate receptors
Anja Probst Larsen, Sabine Fièvre, Karla Frydenvang, Pierre Francotte, Bernard Pirotte, Jette Sandholm Kastrup, Christophe Mulle
Mol Pharmacol. 2017-03-30
10.1124/mol.116.107599

Operation and plasticity of hippocampal CA3 circuits: Implications for memory encoding
Nelson Rebola, Mario Carta, Christophe Mulle
Nat Rev Neurosci. 2017-03-02
10.1038/nrn.2017.10

Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation
Milos M Petrovic, Silvia Viana da Silva, James P Clement, Ladislav Vyklicky, Christophe Mulle, Inmaculada M González-González, Jeremy M Henley
Nat Neurosci. 2017-02-13
10.1038/nn.4505

PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease.
Vincent Maingret, Gaël Barthet, Séverine Deforges, Nan Jiang, Christophe Mulle, Thierry Amédée
Neurobiology of Aging. 2017-02-01
10.1016/j.neurobiolaging.2016.10.012

Control of spike transfer at hippocampal mossy fiber synapses in vivo by GABAA and GABAB receptor-mediated inhibition
Stefano Zucca, Marilena Griguoli, Meryl Malézieux, Noëlle Grosjean, Mario Carta, Christophe Mulle
J. Neurosci.. 2017-01-18
10.1523/JNEUROSCI.2057-16.2017

Control of Spike Transfer at Hippocampal Mossy Fiber Synapses In Vivo by GABA A and GABA B Receptor-Mediated Inhibition
Stefano Zucca, Marilena Griguoli, Meryl Malézieux, Noëlle Grosjean, Mario Carta, Christophe Mulle
J. Neurosci.. 2016-12-02
10.1523/JNEUROSCI.2057-16.2016

Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission.
Chergui K, Bouron A, Normand E, Mulle C.
J Neurosci. 2000-03-15

Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells.
Sabine Fièvre, Mario Carta, Ingrid Chamma, Virginie Labrousse, Olivier Thoumine, Christophe Mulle
Nat Comms. 2016-09-27
10.1038/ncomms12738

Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells
Sabine Fièvre, Mario Carta, Ingrid Chamma, Virginie Labrousse, Olivier Thoumine, Christophe Mulle
Nat Commun. 2016-09-27
10.1038/ncomms12738

Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome
Cristina Borralleras, Susana Mato, Thierry Amédée, Carlos Matute, Christophe Mulle, Luis A. Pérez-Jurado, Victoria Campuzano
Mol Brain. 2016-08-02
10.1186/s13041-016-0258-7

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.
Silvia Viana da Silva, Matthias Georg Haberl, Pei Zhang, Philipp Bethge, Cristina Lemos, Nélio Gonçalves, Adam Gorlewicz, Meryl Malezieux, Francisco Q. Gonçalves, Noëlle Grosjean, Christophe Blanchet, Andreas Frick, U Valentin Nägerl, Rodrigo A. Cunha, Christophe Mulle
Nat Comms. 2016-06-17
10.1038/ncomms11915

Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors.
Jimmy George, Rodrigo A. Cunha, Christophe Mulle, Thierry Amédée
Eur J Neurosci. 2016-03-01
10.1111/ejn.13191

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.
Jennifer Stanic, Mario Carta, Ivano Eberini, Silvia Pelucchi, Elena Marcello, Armando A. Genazzani, Claudia Racca, Christophe Mulle, Monica Di Luca, Fabrizio Gardoni
Nat Commun. 2015-12-01
10.1038/ncomms10181

Exclusive photorelease of signalling lipids at the plasma membrane
André Nadler, Dmytro A. Yushchenko, Rainer Müller, Frank Stein, Suihan Feng, Christophe Mulle, Mario Carta, Carsten Schultz
Nat Commun. 2015-12-01
10.1038/ncomms10056

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex
Jennifer Stanic, Mario Carta, Ivano Eberini, Silvia Pelucchi, Elena Marcello, Armando A. Genazzani, Claudia Racca, Christophe Mulle, Monica Di Luca, Fabrizio Gardoni
Nat Commun. 2015-12-01
10.1038/ncomms10181

Physiopathology of kainate receptors in epilepsy.
Valérie Crépel, Christophe Mulle
Current Opinion in Pharmacology. 2015-02-01
10.1016/j.coph.2014.11.012

Parkin regulates kainate receptors by interacting with the GluK2 subunit.
AnnaMaria Maraschi, Andrea Ciammola, Alessandra Folci, Francesca Sassone, Giuseppe Ronzitti, Graziella Cappelletti, Vincenzo Silani, Shigeto Sato, Nobutaka Hattori, Michele Mazzanti, Evelina Chieregatti, Christophe Mulle, Maria Passafaro, Jenny Sassone
Nat Commun. 2014-10-15
10.1038/ncomms6182

Parkin regulates kainate receptors by interacting with the GluK2 subunit
AnnaMaria Maraschi, Andrea Ciammola, Alessandra Folci, Francesca Sassone, Giuseppe Ronzitti, Graziella Cappelletti, Vincenzo Silani, Shigeto Sato, Nobutaka Hattori, Michele Mazzanti, Evelina Chieregatti, Christophe Mulle, Maria Passafaro, Jenny Sassone
Nat Commun. 2014-10-15
10.1038/ncomms6182

Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling.
Nicolas H. Piguel, Sabine Fievre, Jean-Michel Blanc, Mario Carta, Maïté M. Moreau, Enora Moutin, Vera L. Pinheiro, Chantal Medina, Jerome Ezan, Léa Lasvaux, François Loll, Christelle M. Durand, Kai Chang, Ronald S. Petralia, Robert J. Wenthold, F. Anne Stephenson, Laurent Vuillard, Hervé Darbon, Julie Perroy, Christophe Mulle, Mireille Montcouquiol, Claudia Racca, Nathalie Sans
Cell Reports. 2014-10-01
10.1016/j.celrep.2014.09.017

Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice.
M. Pascual-Lucas, S. Viana da Silva, M. Di Scala, C. Garcia-Barroso, G. Gonzalez-Aseguinolaza, C. Mulle, C. M. Alberini, M. Cuadrado-Tejedor, A. Garcia-Osta
EMBO Molecular Medicine. 2014-08-06
10.15252/emmm.201404228

Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.
Angélique Peret, Louisa A. Christie, David W. Ouedraogo, Adam Gorlewicz, Jérôme Epsztein, Christophe Mulle, Valérie Crépel
Cell Reports. 2014-07-01
10.1016/j.celrep.2014.06.032

Zinc dynamics and action at excitatory synapses.
Angela Maria Vergnano, Nelson Rebola, Leonid P. Savtchenko, Paulo S. Pinheiro, Mariano Casado, Brigitte L. Kieffer, Dmitri A. Rusakov, Christophe Mulle, Pierre Paoletti
Neuron. 2014-06-01
10.1016/j.neuron.2014.04.034

Impaired hippocampus-dependent spatial flexibility and sociability represent autism-like phenotypes in GluK2 mice.
Jacques Micheau, Alice Vimeney, Elisabeth Normand, Christophe Mulle, Gernot Riedel
Hippocampus. 2014-04-30
10.1002/hipo.22290

Kainate receptors in the hippocampus.
Mario Carta, Sabine Fièvre, Adam Gorlewicz, Christophe Mulle
Eur J Neurosci. 2014-04-17
10.1111/ejn.12590

An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology
Matthias Georg Haberl, Silvia Viana da Silva, Jason M. Guest, Melanie Ginger, Alexander Ghanem, Christophe Mulle, Marcel Oberlaender, Karl-Klaus Conzelmann, Andreas Frick
Brain Struct Funct. 2014-04-11
10.1007/s00429-014-0730-z

Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels.
Mario Carta, Frederic Lanore, Nelson Rebola, Zsolt Szabo, Silvia Viana Da Silva, Joana Lourenço, Agathe Verraes, André Nadler, Carsten Schultz, Christophe Blanchet, Christophe Mulle
Neuron. 2014-02-01
10.1016/j.neuron.2013.12.028

Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels. [(Neuron 81, 19, (2014) 787-799]
Mario Carta, Frederic Lanore, Nelson Rebola, Zsolt Szabo, Silvia Viana Da Silva, Joana Lourenço, Agathe Verraes, André Nadler, Carsten Schultz, Christophe Blanchet, Christophe Mulle
Neuron. 2014-02-01
10.1016/j.neuron.2014.02.001

CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.
Mario Carta, Patrizio Opazo, Julien Veran, Axel Athané, Daniel Choquet, Françoise Coussen, Christophe Mulle
EMBO J. 2013-01-04
10.1038/emboj.2012.334

Deficits in morphofunctional maturation of hippocampal mossy fiber synapses in a mouse model of intellectual disability
F. Lanore, V. F. Labrousse, Z. Szabo, E. Normand, C. Blanchet, C. Mulle
Journal of Neuroscience. 2012-12-05
10.1523/JNEUROSCI.2049-12.2012

Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface.
Julien Veran, Janesh Kumar, Paulo S. Pinheiro, Axel Athané, Mark L. Mayer, David Perrais, Christophe Mulle
Neuron. 2012-11-01
10.1016/j.neuron.2012.08.027

Kainate induces mobilization of synaptic vesicles at the growth cone through the activation of protein kinase A.
Giuliana Gelsomino, Elisabetta Menna, Flavia Antonucci, Simona Rodighiero, Loredana Riganti, Christophe Mulle, Fabio Benfenati, Flavia Valtorta, Claudia Verderio, Michela Matteoli
Cerebral Cortex. 2012-03-07
10.1093/cercor/bhs026

Kainate induces mobilization of synaptic vesicles at the growth cone through the activation of protein kinase A
Giuliana Gelsomino, Elisabetta Menna, Flavia Antonucci, Simona Rodighiero, Loredana Riganti, Christophe Mulle, Fabio Benfenati, Flavia Valtorta, Claudia Verderio, Michela Matteoli
Cerebral Cortex. 2012-03-07
10.1093/cercor/bhs026

Kainate induces mobilization of synaptic vesicles at the growth cone through the activation of protein kinase A
Giuliana Gelsomino, Elisabetta Menna, Flavia Antonucci, Simona Rodighiero, Loredana Riganti, Christophe Mulle, Fabio Benfenati, Flavia Valtorta, Claudia Verderio, Michela Matteoli
Cerebral Cortex. 2012-03-07
10.1093/cercor/bhs026

Mitochondrial CB₁ receptors regulate neuronal energy metabolism.
Giovanni Bénard, Federico Massa, Nagore Puente, Joana Lourenço, Luigi Bellocchio, Edgar Soria-Gómez, Isabel Matias, Anna Delamarre, Mathilde Metna-Laurent, Astrid Cannich, Etienne Hebert-Chatelain, Christophe Mulle, Silvia Ortega-Gutiérrez, Mar Martín-Fontecha, Matthias Klugmann, Stephan Guggenhuber, Beat Lutz, Jürg Gertsch, Francis Chaouloff, María Luz López-Rodríguez, Pedro Grandes, Rodrigue Rossignol, Giovanni Marsicano
Nat Neurosci. 2012-03-04
10.1038/nn.3053

Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses
Maddalena D. Caiati, Sudhir Sivakumaran, Frederic Lanore, Christophe Mulle, Elodie Richard, Dany Verrier, Giovanni Marsicano, Richard Miles, Enrico Cherubini
Sci Rep. 2012-02-24
10.1038/srep00285

Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses.
Paulo S. Pinheiro, Frédéric Lanore, Julien Veran, Julien Artinian, Christophe Blanchet, Valérie Crépel, David Perrais, Christophe Mulle
Cerebral Cortex. 2012-02-17
10.1093/cercor/bhs022

Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses
Paulo S. Pinheiro, Frédéric Lanore, Julien Veran, Julien Artinian, Christophe Blanchet, Valérie Crépel, David Perrais, Christophe Mulle
Cerebral Cortex. 2012-02-17
10.1093/cercor/bhs022

Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses
Paulo S. Pinheiro, Frédéric Lanore, Julien Veran, Julien Artinian, Christophe Blanchet, Valérie Crépel, David Perrais, Christophe Mulle
Cerebral Cortex. 2012-02-17
10.1093/cercor/bhs022

Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors
Sandra D. Santos, Olga Iuliano, Luís Ribeiro, Julien Veran, Joana S. Ferreira, Pedro Rio, Christophe Mulle, Carlos B. Duarte, Ana Luísa Carvalho
J. Biol. Chem.. 2012-01-05
10.1074/jbc.M111.322909

Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking
D. Huyghe, J. Veran, V. F. Labrousse, D. Perrais, C. Mulle, F. Coussen
Journal of Neuroscience. 2011-08-10
10.1523/JNEUROSCI.2206-11.2011

Alzheimer's disease, amyloïd peptide and synaptic dysfunction | Maladie d'Alzheimer, peptide β-amyloïde et synapses
Agnès Hémar, Christophe Mulle
Med Sci (Paris). 2011-08-01
10.1051/medsci/2011278015

NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses.
Nelson Rebola, Mario Carta, Frederic Lanore, Christophe Blanchet, Christophe Mulle
Nat Neurosci. 2011-05-01
10.1038/nn.2809

Pharmacological activation of kainate receptors drives endocannabinoid mobilization
J. Lourenco, I. Matias, G. Marsicano, C. Mulle
Journal of Neuroscience. 2011-03-02
10.1523/JNEUROSCI.3512-10.2011

Kainate receptors coming of age: milestones of two decades of research.
Anis Contractor, Christophe Mulle, Geoffrey T. Swanson
Trends in Neurosciences. 2011-03-01
10.1016/j.tins.2010.12.002

Kainate receptors coming of age: Milestones of two decades of research
Anis Contractor, Christophe Mulle, Geoffrey T. Swanson
Trends in Neurosciences. 2011-03-01
10.1016/j.tins.2010.12.002

Kainate receptors coming of age: Milestones of two decades of research
Anis Contractor, Christophe Mulle, Geoffrey T. Swanson
Trends in Neurosciences. 2011-03-01
10.1016/j.tins.2010.12.002

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage
M. Malinverno, M. Carta, R. Epis, E. Marcello, C. Verpelli, F. Cattabeni, C. Sala, C. Mulle, M. Di Luca, F. Gardoni
Journal of Neuroscience. 2010-12-01
10.1523/JNEUROSCI.1984-10.2010

Gating and permeation of kainate receptors: differences unveiled.
David Perrais, Julien Veran, Christophe Mulle
Trends in Pharmacological Sciences. 2010-11-01
10.1016/j.tips.2010.08.004

Gating and permeation of kainate receptors: Differences unveiled
David Perrais, Julien Veran, Christophe Mulle
Trends in Pharmacological Sciences. 2010-11-01
10.1016/j.tips.2010.08.004

Profilin II regulates the exocytosis of kainate glutamate receptors
Magali Mondin, Mario Carta, Elisabeth Normand, Christophe Mulle, Françoise Coussen
J. Biol. Chem.. 2010-10-11
10.1074/jbc.M110.140442

Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon.
Frederic Lanore, Christophe Blanchet, Anna Fejtova, Paulo Pinheiro, Karin Richter, Detlef Balschun, Eckart Gundelfinger, Christophe Mulle
The Journal of Physiology. 2010-06-14
10.1113/jphysiol.2009.184929

Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon
Frederic Lanore, Christophe Blanchet, Anna Fejtova, Paulo Pinheiro, Karin Richter, Detlef Balschun, Eckart Gundelfinger, Christophe Mulle
The Journal of Physiology. 2010-06-14
10.1113/jphysiol.2009.184929

High firing rate of neonatal hippocampal interneurons is caused by attenuation of afterhyperpolarizing potassium currents by tonically active kainate receptors
M. Segerstrale, J. Juuri, F. Lanore, P. Piepponen, S. E. Lauri, C. Mulle, T. Taira
Journal of Neuroscience. 2010-05-12
10.1523/JNEUROSCI.4856-09.2010

High firing rate of neonatal hippocampal interneurons is caused by attenuation of afterhyperpolarizing potassium currents by tonically active kainate receptors.
M. Segerstrale, J. Juuri, F. Lanore, P. Piepponen, S. E. Lauri, C. Mulle, T. Taira
Journal of Neuroscience. 2010-05-12
10.1523/jneurosci.4856-09.2010

Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses.
Joana Lourenço, Astrid Cannich, Mario Carta, Françoise Coussen, Christophe Mulle, Giovanni Marsicano
Nat Neurosci. 2010-01-17
10.1038/nn.2481

Activity-dependent synaptic plasticity of NMDA receptors.
Nelson Rebola, Bettadapura N. Srikumar, Christophe Mulle
The Journal of Physiology. 2010-01-01
10.1113/jphysiol.2009.179382

Activity-dependent synaptic plasticity of NMDA receptors
Nelson Rebola, Bettadapura N. Srikumar, Christophe Mulle
The Journal of Physiology. 2010-01-01
10.1113/jphysiol.2009.179382

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
T. S. Thorsen, K. L. Madsen, N. Rebola, M. Rathje, V. Anggono, A. Bach, I. S. Moreira, N. Stuhr-Hansen, T. Dyhring, D. Peters, T. Beuming, R. Huganir, H. Weinstein, C. Mulle, K. Stromgaard, L. C. B. Ronn, U. Gether
Proceedings of the National Academy of Sciences. 2009-12-14
10.1073/pnas.0902225107

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
T. S. Thorsen, K. L. Madsen, N. Rebola, M. Rathje, V. Anggono, A. Bach, I. S. Moreira, N. Stuhr-Hansen, T. Dyhring, D. Peters, T. Beuming, R. Huganir, H. Weinstein, C. Mulle, K. Stromgaard, L. C. B. Ronn, U. Gether
Proceedings of the National Academy of Sciences. 2009-12-14
10.1073/pnas.0902225107

Atypical functional properties of GluK3-containing kainate receptors
D. Perrais, F. Coussen, C. Mulle
Journal of Neuroscience. 2009-12-09
10.1523/JNEUROSCI.2724-09.2009

Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses
S. Sachidhanandam, C. Blanchet, Y. Jeantet, Y. H. Cho, C. Mulle
Journal of Neuroscience. 2009-04-15
10.1523/JNEUROSCI.5807-08.2009

Antagonism of recombinant and native GluK3-containing kainate receptors.
David Perrais, Paulo S. Pinheiro, David E. Jane, Christophe Mulle
Neuropharmacology. 2009-01-01
10.1016/j.neuropharm.2008.08.002

Kainate receptors in epilepsy and excitotoxicity.
P. Vincent, C. Mulle
Neuroscience. 2009-01-01
10.1016/j.neuroscience.2008.02.066

Protein trafficking, targeting, and interaction at the glutamate synapse.
S. Davanger, D. Manahan-Vaughan, C. Mulle, J. Storm-Mathisen, O.P. Ottersen
Neuroscience. 2009-01-01
10.1016/j.neuroscience.2008.11.012

Kainate receptors in epilepsy and excitotoxicity
P. Vincent, C. Mulle
Neuroscience. 2009-01-01
10.1016/j.neuroscience.2008.02.066

Protein trafficking, targeting, and interaction at the glutamate synapse
S. Davanger, D. Manahan-Vaughan, C. Mulle, J. Storm-Mathisen, O.P. Ottersen
Neuroscience. 2009-01-01
10.1016/j.neuroscience.2008.11.012

GluR6/KA2 kainate receptors mediate slow-deactivating currents
A. Barberis, S. Sachidhanandam, C. Mulle
Journal of Neuroscience. 2008-06-18
10.1523/JNEUROSCI.1204-08.2008

Presynaptic glutamate receptors: physiological functions and mechanisms of action.
Paulo S. Pinheiro, Christophe Mulle
Nat Rev Neurosci. 2008-05-09
10.1038/nrn2379

Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses.
Nelson Rebola, Rafael Lujan, Rodrigo A. Cunha, Christophe Mulle
Neuron. 2008-01-01
10.1016/j.neuron.2007.11.023

Fast regulation of axonal growth cone motility by electrical activity
G. Ibarretxe, D. Perrais, F. Jaskolski, A. Vimeney, C. Mulle
Journal of Neuroscience. 2007-07-18
10.1523/JNEUROSCI.1070-07.2007

GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
P. S. Pinheiro, D. Perrais, F. Coussen, J. Barhanin, B. Bettler, J. R. Mann, J. O. Malva, S. F. Heinemann, C. Mulle
Proceedings of the National Academy of Sciences. 2007-07-09
10.1073/pnas.0608891104

GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses
P. S. Pinheiro, D. Perrais, F. Coussen, J. Barhanin, B. Bettler, J. R. Mann, J. O. Malva, S. F. Heinemann, C. Mulle
Proceedings of the National Academy of Sciences. 2007-07-09
10.1073/pnas.0608891104

Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.
Pietro Pilo Boyl, Alessia Di Nardo, Christophe Mulle, Marco Sassoè-Pognetto, Patrizia Panzanelli, Andrea Mele, Matthias Kneussel, Vivian Costantini, Emerald Perlas, Marzia Massimi, Hugo Vara, Maurizio Giustetto, Walter Witke
EMBO J. 2007-05-31
10.1038/sj.emboj.7601737

Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior
Pietro Pilo Boyl, Alessia Di Nardo, Christophe Mulle, Marco Sassoè-Pognetto, Patrizia Panzanelli, Andrea Mele, Matthias Kneussel, Vivian Costantini, Emerald Perlas, Marzia Massimi, Hugo Vara, Maurizio Giustetto, Walter Witke
EMBO J. 2007-05-31
10.1038/sj.emboj.7601737

Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses
N. Rebola, S. Sachidhanandam, D. Perrais, R. A. Cunha, C. Mulle
Journal of Neuroscience. 2007-04-11
10.1523/JNEUROSCI.5182-06.2007

KRIP6: a novel BTB/kelch protein regulating function of kainate receptors.
Fernanda Laezza, Timothy J. Wilding, Sunitha Sequeira, Françoise Coussen, Xue Zhao Zhang, Rona Hill-Robinson, Christophe Mulle, James E. Huettner, Ann Marie Craig
Molecular and Cellular Neuroscience. 2007-04-01
10.1016/j.mcn.2006.12.003

Kainate receptor-interacting proteins and membrane trafficking
F. Coussen, C. Mulle
Biochm. Soc. Trans.. 2006-10-01
10.1042/BST0340927

Kainate receptors.
Paulo Pinheiro, Christophe Mulle
Cell Tissue Res. 2006-07-18
10.1007/s00441-006-0265-6

Kainate receptors
Paulo Pinheiro, Christophe Mulle
Cell Tissue Res. 2006-07-18
10.1007/s00441-006-0265-6

Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses
A. Ruiz
Journal of Neuroscience. 2005-12-14
10.1523/JNEUROSCI.4041-05.2005

Short-term regulation of information processing at the corticoaccumbens synapse
G. Casassus
Journal of Neuroscience. 2005-12-14
10.1523/JNEUROSCI.2466-05.2005

Co-assembly of two GluR6 kainate receptor splice variants within a functional protein complex.
Françoise Coussen, David Perrais, Frédéric Jaskolski, Shankar Sachidhanandam, Elisabeth Normand, Joel Bockaert, Philippe Marin, Christophe Mulle
Neuron. 2005-08-01
10.1016/j.neuron.2005.06.033

An automated method to quantify and visualize colocalized fluorescent signals.
Frédéric Jaskolski, Christophe Mulle, Olivier J. Manzoni
Journal of Neuroscience Methods. 2005-07-01
10.1016/j.jneumeth.2005.01.012

Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus
S. E. Lauri
Journal of Neuroscience. 2005-05-04
10.1523/JNEUROSCI.4050-04.2005

Differential trafficking of GluR7 kainate receptor subunit splice variants
Frédéric Jaskolski, Elisabeth Normand, Christophe Mulle, Françoise Coussen
J. Biol. Chem.. 2005-04-01
10.1074/jbc.M413166200

Subcellular localization and trafficking of kainate receptors.
Frédéric Jaskolski, Françoise Coussen, Christophe Mulle
Trends in Pharmacological Sciences. 2005-01-01
10.1016/j.tips.2004.11.008

Subcellular localization and trafficking of kainate receptors
Frédéric Jaskolski, Françoise Coussen, Christophe Mulle
Trends in Pharmacological Sciences. 2005-01-01
10.1016/j.tips.2004.11.008

Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.
Cécile Marchal, Christophe Mulle
The Journal of Physiology. 2004-11-01
10.1113/jphysiol.2004.069922

Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: A potential role for kainate receptors
Cécile Marchal, Christophe Mulle
The Journal of Physiology. 2004-11-01
10.1113/jphysiol.2004.069922

Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history.
Elsa Diguet, Pierre-Olivier Fernagut, Elisabeth Normand, Laurie Centelles, Christophe Mulle, François Tison
Neurobiology of Disease. 2004-04-01
10.1016/j.nbd.2003.12.010

Subunit Composition and Alternative Splicing Regulate Membrane Delivery of Kainate Receptors
F. Jaskolski
Journal of Neuroscience. 2004-03-10
10.1523/JNEUROSCI.5116-03.2004

Spike-dependent intrinsic plasticity increases firing probability in rat striatal neurons in vivo.
Séverine Mahon, Guillaume Casassus, Christophe Mulle, Stéphane Charpier
The Journal of Physiology. 2003-08-01
10.1113/jphysiol.2003.043125

Spike-dependent intrinsic plasticity increases firing probability in rat striatal neurons in vivo
Séverine Mahon, Guillaume Casassus, Christophe Mulle, Stéphane Charpier
The Journal of Physiology. 2003-08-01
10.1113/jphysiol.2003.043125

Erratum: Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP (Neuron (February 20, 2003) 37 (625-638))
Hélène Hirbec, Joanna C Francis, Sari E Lauri, Steven P Braithwaite, Françoise Coussen, Christophe Mulle, Kumlesh K Dev, Victoria Coutinho, Guido Meyer, John T.R Isaac, Graham L Collingridge, Jeremy M Henley
Neuron. 2003-05-01
10.1016/S0896-6273(03)00284-8

Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
Hélène Hirbec, Joanna C Francis, Sari E Lauri, Steven P Braithwaite, Françoise Coussen, Christophe Mulle, Kumlesh K Dev, Victoria Couthino, Guido Meyer, John T.R Isaac, Graham L Collingridge, Jeremy M Henley
Neuron. 2003-02-01
10.1016/S0896-6273(02)01191-1

Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.
Hélène Hirbec, Joanna C Francis, Sari E Lauri, Steven P Braithwaite, Françoise Coussen, Christophe Mulle, Kumlesh K Dev, Victoria Couthino, Guido Meyer, John T.R Isaac, Graham L Collingridge, Jeremy M Henley
Neuron. 2003-02-01
10.1016/s0896-6273(02)01191-1

Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes.
Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, Mège RM, Mulle C.
J Neurosci.. 2002 Aug 1

Functional characterization of kainate receptors in the mouse nucleus accumbens.
Guillaume Casassus, Christophe Mulle
Neuropharmacology. 2002-04-01
10.1016/s0028-3908(02)00011-4

Functional characterization of kainate receptors in the mouse nucleus accumbens
Guillaume Casassus, Christophe Mulle
Neuropharmacology. 2002-04-01
10.1016/S0028-3908(02)00011-4

Subunit composition of kainate receptors in hippocampal interneurons.
Christophe Mulle, Andreas Sailer, Geoffrey T Swanson, Corinne Brana, Stephen O'Gorman, Bernhard Bettler, Stephen F Heinemann
Neuron. 2000-11-01
10.1016/s0896-6273(00)00126-4

Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate.
I. Bureau, S. Dieudonne, F. Coussen, C. Mulle
Proceedings of the National Academy of Sciences. 2000-06-06
10.1073/pnas.97.12.6838

Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate
I. Bureau, S. Dieudonne, F. Coussen, C. Mulle
Proceedings of the National Academy of Sciences. 2000-06-06
10.1073/pnas.97.12.6838

Potentiation of GABAergic synaptic transmission by AMPA receptors in mouse cerebellar stellate cells: changes during development.
Ingrid Bureau, Christophe Mulle
The Journal of Physiology. 1998-06-01
10.1111/j.1469-7793.1998.817bm.x

Potentiation of GABAergic synaptic transmission by AMPA receptors in mouse cerebellar stellate cells: changes during development.
Ingrid Bureau, Christophe Mulle
The Journal of Physiology. 1998-06-01
10.1111/j.1469-7793.1998.817bm.x

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice.
Christophe Mulle, Andreas Sailer, Isabel Pérez-Otaño, Heather Dickinson-Anson, Pablo E. Castillo, Ingrid Bureau, Cornelia Maron, Fred H. Gage, Jeffrey R. Mann, Bernhard Bettler, Stephen F. Heinemann
Nature. 1998-04-01
10.1038/33408

Spatial distribution of kainate receptor subunit mRNA in the mouse basal ganglia and ventral mesencephalon.
Serge Bischoff, Jacques Barhanin, Bernhard Bettler, Christophe Mulle, Stephen Heinemann
J. Comp. Neurol.. 1997-03-24
10.1002/(sici)1096-9861(19970324)379:43.0.co;2-2

AMPA and kainate receptors
B. Bettler, C. Mulle
Neuropharmacology. 1995-02-01
10.1016/0028-3908(94)00141-E

Review: neurotransmitter receptors. II. AMPA and kainate receptors.
B. Bettler, C. Mulle
Neuropharmacology. 1995-02-01
10.1016/0028-3908(94)00141-e

Potentiation of nicotinic receptor response by external calcium in rat central neurons
Christophe Mulle, Clément Léna, Jean-Pierre Changeux
Neuron. 1992-05-01
10.1016/0896-6273(92)90208-U

Potentiation of nicotinic receptor response by external calcium in rat central neurons.
Christophe Mulle, Clément Léna, Jean-Pierre Changeux
Neuron. 1992-05-01
10.1016/0896-6273(92)90208-u

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.
D. Bertrand, A. Devillers-Thiery, F. Revah, J. L. Galzi, N. Hussy, C. Mulle, S. Bertrand, M. Ballivet, J. P. Changeux
Proceedings of the National Academy of Sciences. 1992-02-15
10.1073/pnas.89.4.1261

Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation
Christophe Mulle, Daniel Choquet, Henri Korn, Jean-Pierre Changeux
Neuron. 1992-01-01
10.1016/0896-6273(92)90115-T

Calcium influx through nicotinic receptor in rat central neurons: its relevance to cellular regulation.
Christophe Mulle, Daniel Choquet, Henri Korn, Jean-Pierre Changeux
Neuron. 1992-01-01
10.1016/0896-6273(92)90115-t

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor.
F. Revah, D. Bertrand, J.-L Galzi, A. Devillers-Thiéry, C. Mulle, N. Hussy, S. Bertrand, M. Ballivet, J.-P. Changeux
Nature. 1991-10-01
10.1038/353846a0

Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells.
C. Mulle, P. Benoit, C. Pinset, M. Roa, J. P. Changeux
Proceedings of the National Academy of Sciences. 1988-08-01
10.1073/pnas.85.15.5728

Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells.
C. Mulle, P. Benoit, C. Pinset, M. Roa, J. P. Changeux
Proceedings of the National Academy of Sciences. 1988-08-01
10.1073/pnas.85.15.5728

Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative.
Jocelyne Langenbuch-Cachat, Cassian Bon, Christophe Mulle, Maurice Goeldner, Christian Hirth, Jean Pierre Changeux
Biochemistry. 1988-04-05
10.1021/bi00407a015

Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative.
Jocelyne Langenbuch-Cachat, Cassian Bon, Christophe Mulle, Maurice Goeldner, Christian Hirth, Jean Pierre Changeux
Biochemistry. 1988-04-05
10.1021/bi00407a015

Peripheral maps and synapse elimination in the cerebellum of the rat.I. Representation of peripheral inputs through the climbing fiber pathway in the posterior vermis of the normal adult rat
Christophe Mulle, Nicole Delhaye-Bouchaud, Jean Mariani
Brain Research. 1987-09-01
10.1016/0006-8993(87)91290-X

Peripheral maps and synapse elimination in the cerebellum of the rat. II. Representation of peripheral inputs through the climbing fiber pathway in the posterior vermis of X-irradiated adult rats.
Jean Mariani, Christophe Mulle, Brigitte Geoffroy, Nicole Delhaye-Bouchaud
Brain Research. 1987-09-01
10.1016/0006-8993(87)91291-1

Peripheral maps and synapse elimination in the cerebellum of the rat. I. Representation of peripheral inputs through the climbing fiber pathway in the posterior vermis of the normal adult rat.
Christophe Mulle, Nicole Delhaye-Bouchaud, Jean Mariani
Brain Research. 1987-09-01
10.1016/0006-8993(87)91290-x

Peripheral maps and synapse elimination in the cerebellum of the rat. II. Representation of peripheral inputs through the climbing fiber pathway in the posterior vermis of X-irradiated adult rats.
Jean Mariani, Christophe Mulle, Brigitte Geoffroy, Nicole Delhaye-Bouchaud
Brain Research. 1987-09-01
10.1016/0006-8993(87)91291-1

Calcium-dependent effect of the thymic polypeptide thymopoietin on the desensitization of the nicotinic acetylcholine receptor
F. Revah, C. Mulle, C. Pinset, T. Audhya, G. Goldstein, J. P. Changeux
Proceedings of the National Academy of Sciences. 1987-05-01
10.1073/pnas.84.10.3477

Absence of spindle oscillations in the cat anterior thalamic nuclei.
Christophe Mulle, Mircea Steriade, Martin Descheˆnes
Brain Research. 1985-05-01
10.1016/0006-8993(85)90581-5

The effects of QX314 on thalamic neurons.
Christophe Mulle, Mircea Steriade, Martin Deschênes
Brain Research. 1985-05-01
10.1016/0006-8993(85)91591-4