Mario Carta

Team: Synapses and neural circuits in behaviour
Team leader  |  Researcher - PhD (CR)  |  CNRS

Mario Carta (CRCN-CNRS, University of Bordeaux) is a neurobiologist with strong expertise in electrophysiology of synaptic transmission and plasticity and in cortical processing in vitro and in vivo. The general aim of his research is to understand how synapses and neuronal circuits function and how they are regulated in various physiological or pathological states. He was trained as a slice electrophysiologist in the Valenzuela lab (University of New Mexico, USA) where he studied how ethanol, neurosteroids and various pharmacological compounds modulate neuronal and synaptic plasticity and circuit functions in the hippocampus and cerebellum. He worked as a post-doc in the laboratory of Christophe Mulle (University of Bordeaux) to tackle molecular and cell biological aspects of synaptic physiology and plasticity. In 2013, he was recruited as a junior researcher at the CNRS. From 2017 until the end of 2021, he joined the laboratory of James Poulet (MDC, Berlin) where he investigated in vivo cortical circuits during sensory stimulation and behavior, focusing on the role of the mouse insular cortex in thermosensory perception. He learned how to use cutting-edge approaches such as wide field, 2-photon calcium imaging and electrophysiology in anesthetized and awake behaving animals. Mario Carta returned to Bordeaux in 2022, where he now investigates the synaptic mechanisms underlying gustatory processing in the mouse cortex.

Publications

The cellular coding of temperature in the mammalian cortex
M. Vestergaard, M. Carta, G. Güney, J. F. A. Poulet
Nature. 2023-02-08

10.1038/s41586-023-05705-5

Control of spike transfer at hippocampal mossy fiber synapses in vivo by GABAA and GABAB receptor-mediated inhibition
Stefano Zucca, Marilena Griguoli, Meryl Malézieux, Noëlle Grosjean, Mario Carta, Christophe Mulle
J. Neurosci.. 2017-01-18

10.1523/JNEUROSCI.2057-16.2017

Control of Spike Transfer at Hippocampal Mossy Fiber Synapses In Vivo by GABA A and GABA B Receptor-Mediated Inhibition
Stefano Zucca, Marilena Griguoli, Meryl Malézieux, Noëlle Grosjean, Mario Carta, Christophe Mulle
J. Neurosci.. 2016-12-02

10.1523/JNEUROSCI.2057-16.2016

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.
Jennifer Stanic, Mario Carta, Ivano Eberini, Silvia Pelucchi, Elena Marcello, Armando A. Genazzani, Claudia Racca, Christophe Mulle, Monica Di Luca, Fabrizio Gardoni
Nat Commun. 2015-12-01

10.1038/ncomms10181

Exclusive photorelease of signalling lipids at the plasma membrane
André Nadler, Dmytro A. Yushchenko, Rainer Müller, Frank Stein, Suihan Feng, Christophe Mulle, Mario Carta, Carsten Schultz
Nat Commun. 2015-12-01

10.1038/ncomms10056

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex
Jennifer Stanic, Mario Carta, Ivano Eberini, Silvia Pelucchi, Elena Marcello, Armando A. Genazzani, Claudia Racca, Christophe Mulle, Monica Di Luca, Fabrizio Gardoni
Nat Commun. 2015-12-01

10.1038/ncomms10181

Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling.
Nicolas H. Piguel, Sabine Fievre, Jean-Michel Blanc, Mario Carta, Maïté M. Moreau, Enora Moutin, Vera L. Pinheiro, Chantal Medina, Jerome Ezan, Léa Lasvaux, François Loll, Christelle M. Durand, Kai Chang, Ronald S. Petralia, Robert J. Wenthold, F. Anne Stephenson, Laurent Vuillard, Hervé Darbon, Julie Perroy, Christophe Mulle, Mireille Montcouquiol, Claudia Racca, Nathalie Sans
Cell Reports. 2014-10-01

10.1016/j.celrep.2014.09.017

Kainate receptors in the hippocampus.
Mario Carta, Sabine Fièvre, Adam Gorlewicz, Christophe Mulle
Eur J Neurosci. 2014-04-17

10.1111/ejn.12590

Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels.
Mario Carta, Frederic Lanore, Nelson Rebola, Zsolt Szabo, Silvia Viana Da Silva, Joana Lourenço, Agathe Verraes, André Nadler, Carsten Schultz, Christophe Blanchet, Christophe Mulle
Neuron. 2014-02-01

10.1016/j.neuron.2013.12.028

Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels. [(Neuron 81, 19, (2014) 787-799]
Mario Carta, Frederic Lanore, Nelson Rebola, Zsolt Szabo, Silvia Viana Da Silva, Joana Lourenço, Agathe Verraes, André Nadler, Carsten Schultz, Christophe Blanchet, Christophe Mulle
Neuron. 2014-02-01

10.1016/j.neuron.2014.02.001

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway
M. Khelfaoui, F. Gambino, X. Houbaert, B. Ragazzon, C. Muller, M. Carta, F. Lanore, B. N. Srikumar, P. Gastrein, M. Lepleux, C.-L. Zhang, M. Kneib, B. Poulain, S. Reibel-Foisset, N. Vitale, J. Chelly, P. Billuart, A. Luthi, Y. Humeau
Philosophical Transactions of the Royal Society B: Biological Sciences. 2013-12-02

10.1098/rstb.2013.0160

CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.
Mario Carta, Patrizio Opazo, Julien Veran, Axel Athané, Daniel Choquet, Françoise Coussen, Christophe Mulle
EMBO J. 2013-01-04

10.1038/emboj.2012.334

NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses.
Nelson Rebola, Mario Carta, Frederic Lanore, Christophe Blanchet, Christophe Mulle
Nat Neurosci. 2011-05-01

10.1038/nn.2809

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage
M. Malinverno, M. Carta, R. Epis, E. Marcello, C. Verpelli, F. Cattabeni, C. Sala, C. Mulle, M. Di Luca, F. Gardoni
Journal of Neuroscience. 2010-12-01

10.1523/JNEUROSCI.1984-10.2010

Profilin II regulates the exocytosis of kainate glutamate receptors
Magali Mondin, Mario Carta, Elisabeth Normand, Christophe Mulle, Françoise Coussen
J. Biol. Chem.. 2010-10-11

10.1074/jbc.M110.140442

Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses.
Joana Lourenço, Astrid Cannich, Mario Carta, Françoise Coussen, Christophe Mulle, Giovanni Marsicano
Nat Neurosci. 2010-01-17

10.1038/nn.2481

Spike-timing-dependent plasticity induces presynaptic changes at immature hippocampal mossy fiber synapses
F. Lanore, N. Rebola, M. Carta
Journal of Neuroscience. 2009-07-01

10.1523/JNEUROSCI.1997-09.2009

Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery
E. Sanna, M. C. Mostallino, L. Murru, M. Carta, G. Talani, S. Zucca, M. L. Mura, E. Maciocco, G. Biggio
Journal of Neuroscience. 2009-02-11

10.1523/JNEUROSCI.3684-08.2009

Alcohol impairs long-term depression at the cerebellar parallel fiber-Purkinje cell synapse
Amor Belmeguenai, Paolo Botta, John T. Weber, Mario Carta, Martijn De Ruiter, Chris I. De Zeeuw, C. Fernando Valenzuela, Christian Hansel
Journal of Neurophysiology. 2008-12-01

10.1152/jn.90384.2008

Isoniazid-induced reduction in GABAergic neurotransmission alters the function of the cerebellar cortical circuit
M. Carta, L. Murru, E. Barabino, G. Talani, E. Sanna, G. Biggio
Neuroscience. 2008-06-01

10.1016/j.neuroscience.2008.02.024

Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies
Paolo Botta, Richard A. Radcliffe, Mario Carta, Manuel Mameli, Erin Daly, Kirsten L. Floyd, Richard A. Deitrich, C. Fernando Valenzuela
Alcohol. 2007-05-01

10.1016/j.alcohol.2007.04.004

The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system
M CARTA, L MURRU, P BOTTA, G TALANI, G SECHI, P DERIU, E SANNA, G BIGGIO
Neuropharmacology. 2006-09-01

10.1016/j.neuropharm.2006.05.023

Human astrocytes can be induced to differentiate into cells with neuronal phenotype
Rita Pillai, Franca Scintu, Laura Scorciapino, Mario Carta, Luca Murru, Giovanni Biggio, Stefano Cabras, Camilla Reali, Valeria Sogos
Experimental Cell Research. 2006-07-01

10.1016/j.yexcr.2006.03.031

Social isolation-induced increase in α4 and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAA receptor function
Mariangela Serra, Maria Cristina Mostallino, Giuseppe Talani, Maria Giuseppina Pisu, Mario Carta, Maria Luisa Mura, Ivan Floris, Elisabetta Maciocco, Enrico Sanna, Giovanni Biggio
J Neurochem. 2006-07-01

10.1111/j.1471-4159.2006.03850.x

Basis of the gabamimetic profile of ethanol
G. R. Breese, H. E. Criswell, M. Carta, P. D. Dodson, H. J. Hanchar, R. T. Khisti, M. Mameli, Z. Ming, A. L. Morrow, R. W. Olsen, T. S. Otis, L. H. Parsons, S. N. Penland, M. Roberto, G. R. Siggins, C. F. Valenzuela, M. Wallner
Alcoholism Clin Exp Res. 2006-04-01

10.1111/j.0145-6008.2006.00086.x

Alcohol potently modulates climbing fiber→purkinje neuron synapses: Role of metabotropic glutamate receptors
M. Carta
Journal of Neuroscience. 2006-02-15

10.1523/JNEUROSCI.4430-05.2006

Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission
M. Mameli
Journal of Neuroscience. 2005-08-31

10.1523/JNEUROSCI.2434-05.2005

Letter to the editor (multiple letters)
C Fernando Valenzuela, Manuel Mameli, Mario Carta
Alcoholism: Clinical & Experimental Research. 2005-07-01

10.1097/01.ALC.0000171926.66397.94

Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors
M. Mameli
Journal of Neuroscience. 2005-03-02

10.1523/JNEUROSCI.3877-04.2005

Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells
Michael J. Thomas, Manuel Mameli, Mario Carta, C. Fernando Valenzuela, Pui-Kai Li, L. Donald Partridge
Neuropharmacology. 2005-03-01

10.1016/j.neuropharm.2004.11.014

Alcohol Enhances GABAergic Transmission to Cerebellar Granule Cells via an Increase in Golgi Cell Excitability
M. Carta
Journal of Neuroscience. 2004-04-14

10.1523/JNEUROSCI.0067-04.2004

Chronic Ethanol Consumption Reduces 8δ-and μ-Opioid Receptor-Stimulated G-Protein Coupling in Rat Brain
L. C. Saland, A. Abeyta, S. Frausto, M. Raymond-Stintz, C. M. Hastings, M. Carta, C. F. Valenzuela, D. D. Savage
Alcoholism: Clinical & Experimental Research. 2004-01-01

10.1097/01.ALC.0000108658.00243.BF

Neurosteroid modulation of glutamate release in hippocampal neurons: Lack of an effect of a chronic prenatal ethanol exposure paradigm
Mario Carta, L. Donald Partridge, Daniel D. Savage, C. Fernando Valenzuela
Alcoholism: Clinical & Experimental Research. 2003-07-01

10.1097/01.ALC.0000075828.50697.70

Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons
M. Carta, O. J. Ariwodola, J. L. Weiner, C. F. Valenzuela
Proceedings of the National Academy of Sciences. 2003-05-05

10.1073/pnas.1137276100

Cocaine inhibits 5-HT3 receptor function in neurons from transgenic mice overexpressing the receptor
M Carta
European Journal of Pharmacology. 2003-01-17

10.1016/S0014-2999(02)02867-4

Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABAA receptor subtypes
Enrico Sanna, Fabio Busonero, Giuseppe Talani, Mario Carta, Federico Massa, Michela Peis, Elisabetta Maciocco, Giovanni Biggio
European Journal of Pharmacology. 2002-09-01

10.1016/S0014-2999(02)02191-X

Ethanol withdrawal upregulates kainate receptors in cultured rat hippocampal neurons
Mario Carta, Dorian S Olivera, Todd S Dettmer, C.Fernando Valenzuela
Neuroscience Letters. 2002-07-01

10.1016/S0304-3940(02)00399-3

Delta opioid receptor localization in the rat cerebellum
A Abeyta, T.S Dettmer, A Barnes, D Vega, M Carta, N Gallegos, M Raymond-Stintz, D.D Savage, C.F Valenzuela, L.C Saland
Brain Research. 2002-03-01

10.1016/S0006-8993(02)02248-5

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
Philip Washbourne, Peter M. Thompson, Mario Carta, Edmar T. Costa, James R. Mathews, Guillermina Lopez-Benditó, Zoltán Molnár, Mark W. Becher, C. Fernando Valenzuela, L. Donald Partridge, Michael C. Wilson
Nat Neurosci. 2001-12-19

10.1038/nn783

Increase in expression of the GABAA receptor α4 subunit gene induced by withdrawal of, but not by long-term treatment with, benzodiazepine full or partial agonists
Paolo Follesa, Elisabetta Cagetti, Luisa Mancuso, Francesca Biggio, Annalisa Manca, Elisabetta Maciocco, Federico Massa, Maria Speranza Desole, Mario Carta, Fabio Busonero, Enrico Sanna, Giovanni Biggio
Molecular Brain Research. 2001-08-01

10.1016/S0169-328X(01)00164-4

  • Mario Carta