Author Correction: Endocytosis in the axon initial segment maintains neuronal polarity
Kelsie Eichel, Takeshi Uenaka, Vivek Belapurkar, Rui Lu, Shouqiang Cheng, Joseph S. Pak, Caitlin A. Taylor, Thomas C. Südhof, Robert Malenka, Marius Wernig, Engin Özkan, David Perrais, Kang Shen
Nature. 2025-03-18
10.1038/s41586-025-08837-y

Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma
Camille Dantzer, Justine Vaché, Aude Brunel, Isabelle Mahouche, Anne-Aurélie Raymond, Jean-William Dupuy, Melina Petrel, Paulette Bioulac-Sage, David Perrais, Nathalie Dugot-Senant, Mireille Verdier, Barbara Bessette, Clotilde Billottet, Violaine Moreau
eLife. 2024-07-15
10.7554/eLife.95191.3

Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis
Svenja Bolz, Natalie Kaempf, Dmytro Puchkov, Michael Krauss, Giulia Russo, Tolga Soykan, Christopher Schmied, Martin Lehmann, Rainer Müller, Carsten Schultz, David Perrais, Tanja Maritzen, Volker Haucke
Neuron. 2023-09-01
10.1016/j.neuron.2023.08.016

Imaging of post-synaptic membrane trafficking in neuronal dendrites: progress, limitations, and new developments
David Perrais, Silvia Sposini, Julie Angibaud
Neurophoton.. 2023-08-04
10.1117/1.nph.10.4.044404

Rational Engineering of an Improved Genetically Encoded pH Sensor Based on Superecliptic pHluorin
Yi Shen, Yurong Wen, Silvia Sposini, Anjali Amrapali Vishwanath, Ahmed S. Abdelfattah, Eric R. Schreiter, M. Joanne Lemieux, Jaime de Juan-Sanz, David Perrais, Robert E. Campbell
ACS Sens.. 2023-07-23
10.1021/acssensors.3c00484

Cellular and structural insight into dynamin function during endocytic vesicle formation: a tale of 50 years of investigation
David Perrais
Bioscience Reports. 2022-11-01
10.1042/BSR20211227

Endocytosis in the axon initial segment maintains neuronal polarity
Kelsie Eichel, Takeshi Uenaka, Vivek Belapurkar, Rui Lu, Shouqiang Cheng, Joseph S. Pak, Caitlin A. Taylor, Thomas C. Südhof, Robert Malenka, Marius Wernig, Engin Özkan, David Perrais & Kang Shen
Nature. 2022-08-17
10.1038/s41586-022-05074-5

A synaptomic analysis reveals dopamine hub synapses in the mouse striatum
Vincent Paget-Blanc, Marlene E. Pfeffer, Marie Pronot, Paul Lapios, Maria-Florencia Angelo, Roman Walle, Fabrice P. Cordelières, Florian Levet, Stéphane Claverol, Sabrina Lacomme, Mélina Petrel, Christelle Martin, Vincent Pitard, Véronique De Smedt Peyrusse, Thomas Biederer, David Perrais, Pierre Trifilieff, Etienne Herzog
Nat Commun. 2022-06-03
10.1038/s41467-022-30776-9

Alix is required for activity-dependent bulk endocytosis at brain synapses
Marine H. Laporte, Kwang Il Chi, Laura C. Caudal, Na Zhao, Yvonne Schwarz, Marta Rolland, José Martinez-Hernandez, Magalie Martineau, Christine Chatellard, Eric Denarier, Vincent Mercier, Florent Lemaître, Béatrice Blot, Eve Moutaux, Maxime Cazorla, David Perrais, Fabien Lanté, Dieter Bruns, Sandrine Fraboulet, Fiona J. Hemming, Frank Kirchhoff, Rémy Sadoul
PLoS Biol. 2022-06-03
10.1371/journal.pbio.3001659

Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
Domenico Azarnia Tehran, Gaga Kochlamazashvili, Niccolò P. Pampaloni, Silvia Sposini, Jasmeet Kaur Shergill, Martin Lehmann, Natalya Pashkova, Claudia Schmidt, Delia Löwe, Hanna Napieczynska, Arnd Heuser, Andrew J. R. Plested, David Perrais, Robert C. Piper, Volker Haucke, Tanja Maritzen
Sci. Adv.. 2022-05-27
10.1126/sciadv.abl5032

Selective endocytosis of Ca 2+ -permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
Domenico Azarnia Tehran, Gaga Kochlamazashvili, Niccolò P. Pampaloni, Silvia Sposini, Jasmeet Kaur Shergill, Martin Lehmann, Natalya Pashkova, Claudia Schmidt, Delia Löwe, Hanna Napieczynska, Arnd Heuser, Andrew J. R. Plested, David Perrais, Robert C. Piper, Volker Haucke, Tanja Maritzen
Sci. Adv.. 2022-05-27
10.1126/sciadv.abl5032

Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo
Michael H. Raymond, Andrew J. Davidson, Yi Shen, Daniel R. Tudor, Christopher D. Lucas, Sho Morioka, Justin S. A. Perry, Julia Krapivkina, David Perrais, Linus J. Schumacher, Robert E. Campbell, Will Wood, Kodi S. Ravichandran
Science. 2022-03-11
10.1126/science.abl4430

Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons
Diogo Bessa-Neto, Gerti Beliu, Alexander Kuhlemann, Valeria Pecoraro, Sören Doose, Natacha Retailleau, Nicolas Chevrier, David Perrais, Markus Sauer, Daniel Choquet
Nat Commun. 2021-11-18
10.1038/s41467-021-27025-w

The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites
May Bakr, Damien Jullié, Julia Krapivkina, Vincent Paget-Blanc, Lou Bouit, Jennifer D. Petersen, Natacha Retailleau, Christelle Breillat, Etienne Herzog, Daniel Choquet, David Perrais
Cell Reports. 2021-09-01
10.1016/j.celrep.2021.109678

NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco V. Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy
Nat Commun. 2021-05-14
10.1038/s41467-021-23133-9

Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids allows access to masked epitopes in live neurons
Diogo Bessa-Neto, Alexander Kuhlemann, Gerti Beliu, Valeria Pecoraro, Sören Doose, Natacha Retailleau, Nicolas Chevrier, David Perrais, Markus Sauer, Daniel Choquet
. 2021-02-27
10.1101/2021.02.27.433189

Pharmacological Programming of Endosomal Signaling Activated by Small Molecule Ligands of the Follicle Stimulating Hormone Receptor.
Silvia Sposini, Francesco De Pascali, Rachel Richardson, Niamh S. Sayers, David Perrais, Henry N. Yu, Stephen Palmer, Selva Nataraja, Eric Reiter, Aylin C. Hanyaloglu
Front. Pharmacol.. 2020-11-30
10.3389/fphar.2020.593492

Imaging endocytic vesicle formation at high spatial and temporal resolutions with the pulsed-pH protocol
Silvia Sposini, Morgane Rosendale, Léa Claverie, Thi Nhu Ngoc Van, Damien Jullié, David Perrais
Nat Protoc. 2020-08-17
10.1038/s41596-020-0371-z

Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
Morgane Rosendale, Thi Nhu Ngoc Van, Dolors Grillo-Bosch, Silvia Sposini, Léa Claverie, Isabel Gauthereau, Stéphane Claverol, Daniel Choquet, Matthieu Sainlos, David Perrais
Nat Commun. 2019-10-01
10.1038/s41467-019-12434-9

Exchange Dynamics of Dynamin Measured in Living Cells During Endocytic Vesicle Formation
Léa Claverie, Morgane Rosendale, Patrice Maschalchi, Corey Butler, Natacha Retailleau, Jean-Baptiste Sibarita, Daniel Choquet, David Perrais
Microsc Microanal. 2019-08-01
10.1017/S1431927619006937

Imaging in focus: Imaging the dynamics of endocytosis
Morgane Rosendale, David Perrais
The International Journal of Biochemistry & Cell Biology. 2017-12
10.1016/j.biocel.2017.10.010

Semisynthetic fluorescent pH sensors for imaging exocytosis and endocytosis
Magalie Martineau, Agila Somasundaram, Jonathan B. Grimm, Todd D. Gruber, Daniel Choquet, Justin W. Taraska, Luke D. Lavis, David Perrais
Nat Commun. 2017-11-10
10.1038/s41467-017-01752-5

Endocytose dans les dendrites: un outil local de régulation de la transmission synaptique

Med Sci. 2017-11
10.1051/medsci/20173311009

A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis
Benoît Hastoy, Pier A. Scotti, Alexandra Milochau, Zahia Fezoua-Boubegtiten, Jorge Rodas, Rémi Megret, Bernard Desbat, Michel Laguerre, Sabine Castano, David Perrais, Patrik Rorsman, Reiko Oda, Jochen Lang
Sci Rep. 2017-06-06
10.1038/s41598-017-03013-3

Spatial and Temporal Regulation of Receptor Endocytosis in Neuronal Dendrites Revealed by Imaging of Single Vesicle Formation.
Morgane Rosendale, Damien Jullié, Daniel Choquet, David Perrais
Cell Reports. 2017-02-01
10.1016/j.celrep.2017.01.081

Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
Clothilde Cauvin, Morgane Rosendale, Neetu Gupta-Rossi, Murielle Rocancourt, Pierre Larraufie, Rémi Salomon, David Perrais, Arnaud Echard
Current Biology. 2016-01-01
10.1016/j.cub.2015.11.040

Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.
Anaël Chazeau, Mikael Garcia, Katalin Czöndör, David Perrais, Béatrice Tessier, Grégory Giannone, Olivier Thoumine
MBoC. 2015-03-01
10.1091/mbc.E14-06-1086

pHuji, a pH-sensitive red fluorescent protein for imaging of exo- and endocytosis.
Yi Shen, Morgane Rosendale, Robert E. Campbell, David Perrais
J Cell Biol. 2014-11-10
10.1083/jcb.201404107

Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites.
D. Jullie, D. Choquet, D. Perrais
Journal of Neuroscience. 2014-08-13
10.1523/jneurosci.0799-14.2014

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.
Pedro Monteiro, Carine Rossé, Antonio Castro-Castro, Marie Irondelle, Emilie Lagoutte, Perrine Paul-Gilloteaux, Claire Desnos, Etienne Formstecher, François Darchen, David Perrais, Alexis Gautreau, Maud Hertzog, Philippe Chavrier
J Cell Biol. 2013-12-16
10.1083/jcb.201306162

Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.
Severine Chaumont, Caroline André, David Perrais, Eric Boué-Grabot, Antoine Taly, Maurice Garret
J. Biol. Chem.. 2013-08-09
10.1074/jbc.M113.470807

Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface.
Julien Veran, Janesh Kumar, Paulo S. Pinheiro, Axel Athané, Mark L. Mayer, David Perrais, Christophe Mulle
Neuron. 2012-11-01
10.1016/j.neuron.2012.08.027

Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses.
Paulo S. Pinheiro, Frédéric Lanore, Julien Veran, Julien Artinian, Christophe Blanchet, Valérie Crépel, David Perrais, Christophe Mulle
Cerebral Cortex. 2012-02-17
10.1093/cercor/bhs022

Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking
D. Huyghe, J. Veran, V. F. Labrousse, D. Perrais, C. Mulle, F. Coussen
Journal of Neuroscience. 2011-08-10
10.1523/JNEUROSCI.2206-11.2011

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism.
C M Durand, J Perroy, F Loll, D Perrais, L Fagni, T Bourgeron, M Montcouquiol, N Sans
Mol Psychiatry. 2011-05-24
10.1038/mp.2011.57

A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis.
Marcus J. Taylor, David Perrais, Christien J. Merrifield
PLoS Biol. 2011-03-22
10.1371/journal.pbio.1000604

Gating and permeation of kainate receptors: differences unveiled.
David Perrais, Julien Veran, Christophe Mulle
Trends in Pharmacological Sciences. 2010-11-01
10.1016/j.tips.2010.08.004

Atypical functional properties of GluK3-containing kainate receptors
D. Perrais, F. Coussen, C. Mulle
Journal of Neuroscience. 2009-12-09
10.1523/JNEUROSCI.2724-09.2009

Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity.
Renato Frischknecht, Martin Heine, David Perrais, Constanze I Seidenbecher, Daniel Choquet, Eckart D Gundelfinger
Nat Neurosci. 2009-05-31
10.1038/nn.2338

Antagonism of recombinant and native GluK3-containing kainate receptors.
David Perrais, Paulo S. Pinheiro, David E. Jane, Christophe Mulle
Neuropharmacology. 2009-01-01
10.1016/j.neuropharm.2008.08.002

Human GluR6c, a functional splicing variants of GluR6, is mainly expressed in non-nervous cells.
Alessandro Barbon, Annalisa Gervasoni, Luca LaVia, Cesare Orlandi, Frédéric Jaskolski, David Perrais, Sergio Barlati
Neuroscience Letters. 2008-03-01
10.1016/j.neulet.2008.01.049

Shiga toxin induces tubular membrane invaginations for its uptake into cells.
Winfried Römer, Ludwig Berland, Valérie Chambon, Katharina Gaus, Barbara Windschiegl, Danièle Tenza, Mohamed R. E. Aly, Vincent Fraisier, Jean-Claude Florent, David Perrais, Christophe Lamaze, Graça Raposo, Claudia Steinem, Pierre Sens, Patricia Bassereau, Ludger Johannes
Nature. 2007-11-01
10.1038/nature05996

Imaging Exocytosis with Total Internal Reflection Microscopy (TIRFM).
David Zenisek, David Perrais
Cold Spring Harb Protoc. 2007-10-01
10.1101/pdb.prot4863

Principles of Total Internal Reflection Microscopy (TIRFM).
David Zenisek, David Perrais
Cold Spring Harb Protoc. 2007-10-01
10.1101/pdb.top24

Fast regulation of axonal growth cone motility by electrical activity
G. Ibarretxe, D. Perrais, F. Jaskolski, A. Vimeney, C. Mulle
Journal of Neuroscience. 2007-07-18
10.1523/JNEUROSCI.1070-07.2007

GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
P. S. Pinheiro, D. Perrais, F. Coussen, J. Barhanin, B. Bettler, J. R. Mann, J. O. Malva, S. F. Heinemann, C. Mulle
Proceedings of the National Academy of Sciences. 2007-07-09
10.1073/pnas.0608891104

Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses
N. Rebola, S. Sachidhanandam, D. Perrais, R. A. Cunha, C. Mulle
Journal of Neuroscience. 2007-04-11
10.1523/JNEUROSCI.5182-06.2007

Dynamics of endocytic vesicle creation.
David Perrais, Christien J. Merrifield
Developmental Cell. 2005-11-01
10.1016/j.devcel.2005.10.002

Co-assembly of two GluR6 kainate receptor splice variants within a functional protein complex.
Françoise Coussen, David Perrais, Frédéric Jaskolski, Shankar Sachidhanandam, Elisabeth Normand, Joel Bockaert, Philippe Marin, Christophe Mulle
Neuron. 2005-08-01
10.1016/j.neuron.2005.06.033

Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells.
Christien J. Merrifield, David Perrais, David Zenisek
Cell. 2005-05-01
10.1016/j.cell.2005.03.015

Recapture after exocytosis causes differential retention of protein in granules of bovine chromaffin cells.
David Perrais, Ingo C. Kleppe, Justin W. Taraska, Wolfhard Almers
The Journal of Physiology. 2004-10-01
10.1113/jphysiol.2004.064410

Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells.
J. W. Taraska, D. Perrais, M. Ohara-Imaizumi, S. Nagamatsu, W. Almers
Proceedings of the National Academy of Sciences. 2003-01-21
10.1073/pnas.0337526100

Altering the concentration of GABA in the synaptic cleft potentiates miniature IPSCs in rat occipital cortex.
David Perrais, Nicole Ropert
European Journal of Neuroscience. 2000-01-01
10.1046/j.1460-9568.2000.00957.x

Expression of GABA(A) receptor subunit mRNAs by layer V pyramidal cells of the rat primary visual cortex.
Diego Ruano, David Perrais, Jean Rosier, Nicole Ropert
European Journal of Neuroscience. 1997-04-01
10.1111/j.1460-9568.1997.tb01435.x

Correlation between kinetics and RNA splicing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in neocortical neurons.
B. Lambolez, N. Ropert, D. Perrais, J. Rossier, S. Hestrin
Proceedings of the National Academy of Sciences. 1996-03-05
10.1073/pnas.93.5.1797

Diversity of glutamate receptors in neocortical neurons: implications for synaptic plasticity.
E Audinat, B Lambolez, B Cauli, N Ropert, D Perrais, S Hestrin, J Rossier
Journal of Physiology-Paris. 1996-01-01
10.1016/S0928-4257(97)87911-9