Frédéric Villega

Team: Developmental Brain Physiology and Pathology
Researcher  |  CHU


Publications

Long-Term Clinical and Biological Prognostic Factors of Anti-NMDA Receptor Encephalitis in Children
Maxime Mazowiecki, Lorraine Flet-Berliac, Julia Roux, Anne Lépine, Pascale Chretien, Salima Hacein-Bey-Abina, Laetitia Giorgi, Frederic Villega, Emmanuel Cheuret, Marie Benaiteau, Veronique Rogemond, Geraldine Picard, Sarah Baer, Pierre Cleuziou, Elodie Lametery, Isabelle Desguerre, Mélodie Aubart, Mathilde Chevignard, Roger Le Grand, Philippe Horellou, Carole Leroy, Bastien Joubert, Jerome Honnorat, Kumaran Deiva
Neurol Neuroimmunol Neuroinflamm. 2025-03-01

10.1212/NXI.0000000000200346

Fetal alcohol spectrum disorder and health professionals’ awareness of the syndrome: A comparison of practitioners’ knowledge in two french regions
S. Daoudi, M. Spodenkiewicz, S. Robin, M. Rébola, P. Castera, Peter Von Theobald, M. Husson, B. Doray, F. Villéga
Archives de Pédiatrie. 2025-02-01

10.1016/j.arcped.2024.11.008

Behavioral, neurodevelopmental profile, and epilepsy trajectory in two series of SLC6A1-NDD: a retrospective study with comprehensive assessment, and a participatory database study
Sarah Baer, Mathieu Rebert, Pauline Burger, Jean-Louis Mandel, Nathalie Villeneuve, Marc Gibaud, Cecilia Altuzarra, Frédéric Villega, Claude Cances, Laure Lacan, Sylvie Nguyen, Gaëtan Lesca, Hervé Isnard, Nouha Allani-Essid, Vincent Laugel, Romain Coutelle, Anne de Saint Martin
European Journal of Paediatric Neurology. 2025-01-01

10.1016/j.ejpn.2025.01.003

Diverse anti-NMDAR autoantibodies from individuals with encephalitis
Zoe Jamet, Frederic Villega, Laurent Groc
Nat Struct Mol Biol. 2024-11-27

10.1038/s41594-024-01435-y

Ketamine alleviates NMDA receptor hypofunction through synaptic trapping
Frédéric Villéga, Alexandra Fernandes, Julie Jézéquel, Floriane Uyttersprot, Nathan Benac, Sarra Zenagui, Laurine Bastardo, Hélène Gréa, Delphine Bouchet, Léa Villetelle, Olivier Nicole, Véronique Rogemond, Jérôme Honnorat, Julien P. Dupuis, Laurent Groc
Neuron. 2024-10-01

10.1016/j.neuron.2024.06.028

NMDA receptor autoantibodies primarily impair the extrasynaptic compartment
Zoe Jamet, Camille Mergaux, Morgane Meras, Delphine Bouchet, Frédéric Villega, Jakob Kreye, Harald Prüss, Laurent Groc
Brain. 2024-05-17

10.1093/BRAIN/AWAE163

Phosphatidylserine enriched with polyunsaturated n‐3 fatty acid supplementation for Attention‐Deficit Hyperactivity Disorder (ADHD) in children & adolescents with epilepsy: a randomized placebo‐controlled trial
Sylvain Rheims, Vania Herbillon, Ségolène Gaillard, Catherine Mercier, Nathalie Villeuve, Frédéric Villéga, Claude Cances, Pierre Castelnau, Silvia Napuri, Anne de Saint‐Martin, Stéphane Auvin, Sylvie N. Guyen The Tich, Patrick Berquin, Julitta de Bellecize, Mathieu Milh, Pascal Roy, Alexis Arzimanoglou, Jacques Bodennec, Laurent Bezin, Behrouz Kassai,
Epilepsia Open. 2024-01-03

10.1002/epi4.12892

Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo‐controlled clinical trial
Joseph Sullivan, Lieven Lagae, J. Helen Cross, Orrin Devinsky, Renzo Guerrini, Kelly G. Knupp, Linda Laux, Marina Nikanorova, Tilman Polster, Dinesh Talwar, Berten Ceulemans, Rima Nabbout, Gail M. Farfel, Bradley S. Galer, Arnold R. Gammaitoni, Michael Lock, Anupam Agarwal, Ingrid E. Scheffer,
Epilepsia. 2023-08-17

10.1111/epi.17737

Long-term outcome of paediatric anti-N-methyl-D-aspartate receptor encephalitis
Lorraine Flet‐Berliac, Nicolas Tchitchek, Anne Lépine, Anca Florea, Hélène Maurey, Pascale Chrétien, Salima Hacein‐Bey‐Abina, Frederic Villega, Emmanuel Cheuret, Véronique Rogemond, Géraldine Picard, Jérôme Honnorat, Kumaran Deiva
Develop Med Child Neuro. 2022-10-05

10.1111/DMCN.15429

Cognitive and psychiatric features of anti-NMDA receptor encephalitis
Frederic Villéga, Harald Prüss, Ludger Tebartz van Elst, Laurent Groc
The Lancet Neurology. 2022-10-01

10.1016/S1474-4422(22)00349-0

Early-onset epileptic encephalopathy related to germline PIGA mutations: A series of 5 cases
Sébastien Cabasson, Julien Van-Gils, Frédéric Villéga, Marie-Thérèse Abi-Warde, Giulia Barcia, Leila Lazaro, Claude Cancés, Jamel Chelly, Caroline Karsenty, Serge Rivera, Anne de Saint-Martin, Aurélien Trimouille, Laurent Villard, Jean-Michel Pédespan
European Journal of Paediatric Neurology. 2020-09-01

10.1016/J.EJPN.2020.06.002

[Secondary surfactant deficiencies in extremely low birth weight premature infants.]

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10.1016/j.arcped.2004.08.004

Management of Status Epilepticus in the Prehospital Setting, in the Emergency Department and in Intensive Care Unit (Except Newborns)
H. Outin, P. Gueye, V. Alvarez, S. Auvin, B. Clair, P. Convers, A. Crespel, S. Demeret, S. Dupont, J.-C. Engels, N. Engrand, Y. Freund, P. Gelisse, M. Girot, M.-O. Marcoux, V. Navarro, A. Rossetti, F. Santoli, R. Sonneville, W. Szurhaj, P. Thomas, L. Titomanlio, F. Villega, H. Lefort, V. Peigne
Ann. Fr. Med. Urgence. 2020-05-01

10.3166/AFMU-2020-0232

Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report
Anthony Grondin, Eloïse Baudou, Marlène Pasquet, Sonia Pelluau, Karim Jamal-Bey, Cécile Bermot, Frederic Villega, Emmanuel Cheuret
Neuropediatrics. 2019-12-30

10.1055/s-0039-3402011

Clinical study of 19 patients with SCN 8A ‐related epilepsy: Two modes of onset regarding EEG and seizures
Julien Denis, Nathalie Villeneuve, Pierre Cacciagli, Cecile Mignon‐Ravix, Caroline Lacoste, Jeremie Lefranc, Sylvia Napuri, Lena Damaj, Frederic Villega, Jean‐Michel Pedespan, Sebastien Moutton, Cyril Mignot, Diane Doummar, Laurence Lion‐François, Svetlana Gataullina, Olivier Dulac, Melanie Martin, Sophie Gueden, Gaetan Lesca, Sophie Julia, Claude Cances, Hubert Journel, Cecilia Altuzarra, Bruria Ben Zeev, Alexandra Afenjar, Magalie Barth, Laurent Villard, Mathieu Milh
Epilepsia. 2019-04-26

10.1111/epi.14727

Initial clinical presentation of young children with N-methyl-D-aspartate receptor encephalitis
Marion Favier, Bastien Joubert, Géraldine Picard, Véronique Rogemond, Laure Thomas, Sylvain Rheims, Marion Bailhache, Frédéric Villega, Jean-Michel Pédespan, Giulia Berzero, Dimitri Psimaras, Jean-Christophe Antoine, Virginie Desestret, Jérôme Honnorat
European Journal of Paediatric Neurology. 2018-05-01

10.1016/j.ejpn.2017.12.014

Hereditary neuropathy with liability to pressure palsies in childhood: Report of three cases
C. Bar, F. Villéga, C. Espil, M. Husson, J.-M. Pedespan, M.-F. Rouanet
Archives de Pédiatrie. 2017-03-01

10.1016/J.ARCPED.2016.12.002

Circulating bacterial lipopolysaccharide-induced inflammation reduces flow in brain-irrigating arteries independently from cerebrovascular prostaglandin production.
Frédéric Villéga, Jean-Christophe Delpech, Marion Griton, Caroline André, Jean-Michel Franconi, Sylvain Miraux, Jan Pieter Konsman
Neuroscience. 2017-03-01

10.1016/j.neuroscience.2017.01.018

Case Report of a Severe Recurrent Tongue Self-Injury in an Infant With Dystonia
Oliver Brissaud, Noëlie-Brunehilde Thébaud, Julie Guichoux, Rawen Smirani, Frédéric Villega, Raphaël Devillard
Pediatrics. 2016-11-01

10.1542/PEDS.2016-0738

Perinatal arterial ischemic stroke related to carotid artery occlusion
Joel Fluss, Stephanie Garcia-Tarodo, Michèle Granier, Frédéric Villega, Solène Ferey, Béatrice Husson, Manoelle Kossorotoff, Vincent Muehlethaler, Sebastien Lebon, Stéphane Chabrier
European Journal of Paediatric Neurology. 2016-07-01

10.1016/J.EJPN.2016.03.003

ADHD in childhood epilepsy: Clinical determinants of severity and of the response to methylphenidate
Sylvain Rheims, Vania Herbillon, Nathalie Villeneuve, Stéphane Auvin, Silvia Napuri, Claude Cances, Patrick Berquin, Pierre Castelneau, Sylvie Nguyen The Tich, Frédéric Villega, Hervé Isnard, Rima Nabbout, Ségolène Gaillard, Catherine Mercier, Behrouz Kassai, Alexis Arzimanoglou,
Epilepsia. 2016-05-29

10.1111/EPI.13420

Role of fundus examination in Aicardi syndrome
V. Coste, J.-F. Chateil, F. Villega, C. Andrèbe, J.-F. Korobelnik, C. Paya
Journal Français d'Ophtalmologie. 2016-04-01

10.1016/J.JFO.2016.01.001

Treatment and outcome of children and adolescents with N-methyl-D-aspartate receptor encephalitis.
Anastasia Zekeridou, Evgenia Karantoni, Aurélien Viaccoz, François Ducray, Cyril Gitiaux, Frédéric Villega, Kumaran Deiva, Veronique Rogemond, Elodie Mathias, Géraldine Picard, Marc Tardieu, Jean-Christophe Antoine, Jean-Yves Delattre, Jerome Honnorat
J Neurol. 2015-05-19

10.1007/s00415-015-7781-9

Quality of life and functional outcome in early school-aged children after neonatal stroke: a prospective cohort study.
S. Darteyre, C. Renaud, C. Vuillerot, E. Presles, M. Kossorotoff, M. Dinomais, L. Lazaro, V. Gautheron, S. Chabrier
European Journal of Paediatric Neurology. 2014-05-01

10.1016/j.ejpn.2014.01.006

Refractory status epilepticus: electroconvulsive therapy as a possible therapeutic strategy.
Virginie Lambrecq, Frédéric Villéga, Cécile Marchal, Véronique Michel, Dominique Guehl, Jean-Yves Rotge, Pierre Burbaud
Seizure. 2012-11-01

10.1016/j.seizure.2012.07.010

Dysmorphic features in subtelomeric 20p13 deletion excluding JAG1: a recognizable microdeletion phenotype?
Sébastien Moutton, Caroline Rooryck, Jérôme Toutain, Dorothée Cailley, Julie Bouron, Frédéric Villega, Emmanuelle Taupiac, Didier Lacombe, Benoît Arveiler, Cyril Goizet
European Journal of Medical Genetics. 2012-02-01

10.1016/j.ejmg.2011.12.009

Benign nocturnal alternating hemiplegia of childhood: two cases with positive evolution.
Frédéric Villéga, Fabienne Picard, Caroline Espil-Taris, Marie Husson, Véronique Michel, Jean-Michel Pedespan
Brain and Development. 2011-06-01

10.1016/j.braindev.2010.08.008

[Polymorphic expression of epilepsy and cognitive impairment in ring chromosome 20 syndrome].
F. Villéga, H. Ngayap, C. Espil-Taris, M. Husson, C. Rooryck-Thambo, B. Arveiler, D. Lacombe, J.-M. Pédespan
Archives de Pédiatrie. 2011-04-01

10.1016/j.arcped.2010.12.025

Severe transient ADAMTS13 deficiency in pneumococcal-associated hemolytic uremic syndrome.
Sybille Pelras, Yahsou Delmas, Delphine Lamireau, Frédéric Villega, Paul Nolent, Anne Ryman, Brigitte Llanas, Olivier Brissaud, Jérôme Harambat
Pediatr Nephrol. 2010-12-15

10.1007/s00467-010-1721-9

Motor outcomes after neonatal arterial ischemic stroke related to early MRI data in a prospective study.
B. Husson, L. Hertz-Pannier, C. Renaud, D. Allard, E. Presles, P. Landrieu, S. Chabrier,
PEDIATRICS. 2010-09-20

10.1542/peds.2009-3611

Low prevalence of coagulation F2 and F5 polymorphisms in mothers and children in a large cohort of patients with neonatal arterial ischemic stroke.
C. Renaud, B. Tardy-Poncet, E. Presles, S. Chabrier,
British Journal of Haematology. 2010-09-01

10.1111/j.1365-2141.2010.08259.x

[What non invasive haemodynamic assessment in paediatric intensive care unit in 2009?].
O. Brissaud, J. Guichoux, F. Villega, G. Orliaguet
Annales Françaises d'Anesthésie et de Réanimation. 2010-03-01

10.1016/j.annfar.2009.12.022

Lipoprotein (a), birth weight and neonatal stroke.
Cyrille Renaud, Christine Bonneau, Emilie Presles, Silvy Laporte, Arnaud Depeyre, Marie-Noëlle Varlet, Stéphane Chabrier
Neonatology. 2010-01-01

10.1159/000281015

Efficiency of fractional anisotropy and apparent diffusion coefficient on diffusion tensor imaging in prognosis of neonates with hypoxic-ischemic encephalopathy: a methodologic prospective pilot study.
O. Brissaud, M. Amirault, F. Villega, O. Periot, J.F. Chateil, M. Allard
AJNR Am J Neuroradiol. 2009-12-03

10.3174/ajnr.A1805

[Medical training on mannequins: interests and limits].
O. Brissaud, F. Villega, P. Nolent, J. Naud
Archives de Pédiatrie. 2009-06-01

10.1016/S0929-693X(09)74195-8

[Management of childhood idiopathic thrombocytopenic purpura: a survey of members of the French Society of Pediatric Hematology and Immunology (SHIP)].
P. Lutz, F. Villega, S. Ducassou, N. Entz-Werle, G. Michel
Archives de Pédiatrie. 2007-05-01

10.1016/j.arcped.2006.12.005

[Ondine's Curse and rare oculomotor abnormalities: a case report]
G. Michel, F. Villega, P. Desprez, H. Dollfus, C. Speeg-Schatz
Journal Français d'Ophtalmologie. 2006-04-01

10.1016/S0181-5512(06)77703-8

Congenital hyperekplexia: five sporadic cases.
Serge Rivera, Frédéric Villega, Anne de Saint-Martin, Jacqueline Matis, Benoît Escande, Denys Chaigne, Dominique Astruc
Eur J Pediatr. 2005-10-07

10.1007/s00431-005-0015-x